4-甲基溴苄
化合物
4-甲基溴苄是一種有機化合物，化學式為C8H9Br。它可由4-甲基苯甲醇和三甲基溴矽烷在室溫反應得到，[4]溴化試劑也可以選用三溴化磷[5]或六溴丙酮[6]。它和疊氮化鈉在二甲基亞碸中反應，可以得到4-甲基疊氮化苄[7]；和苯甲酸在碳酸銫存在下於乙腈中反應，得到苯甲酸-4-甲基苯甲酯。[8]
| 4-甲基溴苄 | |
|---|---|
| |
| 英文名 | 4-Methylbenzyl bromide |
| 別名 | 對甲基溴苄 4-甲基苄溴 4-甲基溴化苄 4-溴甲基甲苯 |
| 識別 | |
| CAS號 | 104-81-4 
|
| SMILES |
|
| 性質 | |
| 化學式 | C8H9Br |
| 摩爾質量 | 185.06 g·mol−1 |
| 密度 | 1.324 g·cm−3[1] |
| 熔點 | 35.3 °C（308.4 K）[2] |
| 沸點 | 220 °C（493 K）[3] |
| 相關物質 | |
| 其他陰離子 | 4-甲基氯化苄 |
| 其他陽離子 | 溴化苄 |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
參考文獻 編輯
- ^ "Hazardous Substances Data Bank" data were obtained from the National Library of Medicine (US). Retrieved from SciFinder. [2020-05-23].
- ^ C. W. L. Bevan. 270. Polar effects of alkyl groups in the absence of vicinal steric effects. Journal of the Chemical Society (Resumed). 1960: 1347 [2020-05-29]. ISSN 0368-1769. doi:10.1039/jr9600001347 （英語）.
- ^ "PhysProp" data were obtained from Syracuse Research Corporation of Syracuse, New York (US). Retrieved from SciFinder. [2020-05-23].
- ^ Njomza Ajvazi, Stojan Stavber. Direct halogenation of alcohols with halosilanes under catalyst- and organic solvent-free reaction conditions. Tetrahedron Letters. 2016-06, 57 (22): 2430–2433 [2020-05-29]. doi:10.1016/j.tetlet.2016.04.083. （原始內容存檔於2018-06-30） （英語）.
- ^ Francis Giraud, Cedric Loge, Fabrice Pagniez, Damien Crepin, Sophie Barres, Carine Picot, Patrice Le Pape, Marc Le Borgne. Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II. Journal of Enzyme Inhibition and Medicinal Chemistry. 2009-10, 24 (5): 1067–1075 [2020-05-29]. ISSN 1475-6366. doi:10.1080/14756360802610795 （英語）.
- ^ Kara M. Joseph, Isabel Larraza-Sanchez. Synthesis of benzyl bromides with hexabromoacetone: an alternative path to drug intermediates. Tetrahedron Letters. 2011-01, 52 (1): 13–16 [2020-05-29]. doi:10.1016/j.tetlet.2010.10.133. （原始內容存檔於2018-06-05） （英語）.
- ^ Ming Li, Kun Dong, Yubin Zheng, Wangze Song. Copper-catalyzed cascade click/nucleophilic substitution reaction to access fully substituted triazolyl-organosulfurs. Organic & Biomolecular Chemistry. 2019, 17 (46): 9933–9941 [2020-05-29]. ISSN 1477-0520. doi:10.1039/C9OB02081K （英語）.
- ^ Jincheng Mao, Xiaojiang Yang, Hong Yan, Yue He, Yongming Li, Jinzhou Zhao. Effective Synthesis of Benzyl 3-Phenylpropiolates Via Copper(I)-Catalyzed Esterification of Alkynoic Acids with Benzyl Halides Under Ligand-Free Conditions. Catalysis Letters. 2016-05, 146 (5): 886–892 [2020-05-29]. ISSN 1011-372X. doi:10.1007/s10562-015-1690-5 （英語）.