TRPC5

短瞬態受體電位通道 5 (Short transient receptor potential channel 5, TrpC5 ) 又稱瞬態受體蛋白 5 ( TRP-5 ) ，是一種在人類中由TRPC5基因編碼的離子通道蛋白。 ^[1] ^[2] ^[3] TrpC5 是哺乳動物瞬態受體電位離子通道（英語：Transient receptor potential channel）TRPC家族（英語：TRPC）的亞型。

功能

TrpC5 是七種哺乳動物TRPC （transient receptor potential canonical）蛋白中的一種。 TrpC5 是一種多次穿膜的膜蛋白，且被認為構成了受體活化型的非選擇性鈣離子通道。其單獨存在時即具有活性，但也能與TRPC1 、 TRPC3和TRPC4組成異質多聚體。此外，其也和多種蛋白質相互作用，包括鈣調蛋白(CaM)、 CABP1（英語：CABP1）、 enkurin（英語：enkurin）、Na ⁺–H ⁺交換調節因子 ( NHERF )、干擾素誘導的 GTP 結合蛋白 ( MX1 )、RNF24（英語：RNF24）、SEC14（英語：SEC14）結構域和血影蛋白重複序列蛋白 1 ( SESTD1（英語：SESTD1） )。 ^[1]

TRPC4 和 TRPC5 與汞毒性^[4]和神經行為有關。 ^[5] TRPC5於2021年被發現是牙齒冷感覺系統的組成部分。 ^[6] 其還被發現參與如氯仿、氟烷和異丙酚等麻醉劑的作用。 ^[7]

活化

同源多聚體 TRPC5 和異源多聚體 TRPC5- TRPC1通道被細胞外的硫氧還蛋白（英語：thioredoxase）活化。 ^[8]

交互作用

TRPC5 已被證明與STMN3 、 ^[9] TRPC1 、 ^[10] ^[11]和TRPC4間有交互作用。 ^[11]

參見

TRP通道（英語：transient receptor potential channel）
TRPC（英語：TRPC）

參考資料

^ ^1.0 ^1.1 Entrez Gene: transient receptor potential cation channel. 引用錯誤：帶有name屬性「entrez」的<ref>標籤用不同內容定義了多次
^ Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK. Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel. Genomics. September 1999, 60 (3): 330–40. PMID 10493832. doi:10.1006/geno.1999.5924.
^ Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol. Rev. December 2005, 57 (4): 427–50. PMID 16382100. S2CID 17936350. doi:10.1124/pr.57.4.6.
^ Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B. Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure. Toxicol. Sci. January 2012, 125 (1): 56–68. PMID 21984481. doi:10.1093/toxsci/kfr268  .
^ Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. May 15, 2009, 137 (4): 761–72. PMC 2719954  . PMID 19450521. doi:10.1016/j.cell.2009.03.039.
^ Bernal, Laura; Sotelo-Hitschfeld, Pamela; König, Christine; Sinica, Viktor; Wyatt, Amanda; Winter, Zoltan; Hein, Alexander; Touska, Filip; Reinhardt, Susanne; Tragl, Aaron; Kusuda, Ricardo. Odontoblast TRPC5 channels signal cold pain in teeth. Science Advances. 2021, 7 (13): eabf5567. PMC 7997515  . PMID 33771873. doi:10.1126/sciadv.abf5567.
^ Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ. Modulation of TRPC5 cation channels by halothane, chloroform and propofol. Br. J. Pharmacol. April 2008, 153 (7): 1505–12. PMC 2437913  . PMID 18204473. doi:10.1038/sj.bjp.0707689.
^ Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ. TRPC channel activation by extracellular thioredoxin. Nature. January 2008, 451 (7174): 69–72. PMC 2645077  . PMID 18172497. doi:10.1038/nature06414.
^ Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat. Neurosci. August 2003, 6 (8): 837–45. PMID 12858178. S2CID 7523946. doi:10.1038/nn1092.
^ Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem. October 2003, 278 (40): 39014–9. PMID 12857742. doi:10.1074/jbc.M306705200  .
^ ^11.0 ^11.1 Hofmann T, Schaefer M, Schultz G, Gudermann T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc. Natl. Acad. Sci. U.S.A. May 2002, 99 (11): 7461–6. PMC 124253  . PMID 12032305. doi:10.1073/pnas.102596199  .

延伸閱讀

Beech DJ. Canonical transient receptor potential 5. Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology 179. 2007: 109–23. ISBN 978-3-540-34889-4. PMID 17217053. doi:10.1007/978-3-540-34891-7_6. |journal=被忽略 (幫助); |issue=被忽略 (幫助)
Beech DJ. Bipolar phospholipid sensing by TRPC5 calcium channel. Biochem. Soc. Trans. 2007, 35 (Pt 1): 101–4. PMID 17233612. doi:10.1042/BST0350101.

外部連接

醫學主題詞表（MeSH）：TRPC5+protein,+human

[entrez-1] 1.0 ^1.1 Entrez Gene: transient receptor potential cation channel. 引用錯誤：帶有name屬性「entrez」的<ref>標籤用不同內容定義了多次

[pmid10493832-2] Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK. Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel. Genomics. September 1999, 60 (3): 330–40. PMID 10493832. doi:10.1006/geno.1999.5924.

[pmid16382100-3] Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol. Rev. December 2005, 57 (4): 427–50. PMID 16382100. S2CID 17936350. doi:10.1124/pr.57.4.6.

[4] Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B. Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure. Toxicol. Sci. January 2012, 125 (1): 56–68. PMID 21984481. doi:10.1093/toxsci/kfr268  .

[5] Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. May 15, 2009, 137 (4): 761–72. PMC 2719954  . PMID 19450521. doi:10.1016/j.cell.2009.03.039.

[6] Bernal, Laura; Sotelo-Hitschfeld, Pamela; König, Christine; Sinica, Viktor; Wyatt, Amanda; Winter, Zoltan; Hein, Alexander; Touska, Filip; Reinhardt, Susanne; Tragl, Aaron; Kusuda, Ricardo. Odontoblast TRPC5 channels signal cold pain in teeth. Science Advances. 2021, 7 (13): eabf5567. PMC 7997515  . PMID 33771873. doi:10.1126/sciadv.abf5567.

[pmid18204473-7] Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ. Modulation of TRPC5 cation channels by halothane, chloroform and propofol. Br. J. Pharmacol. April 2008, 153 (7): 1505–12. PMC 2437913  . PMID 18204473. doi:10.1038/sj.bjp.0707689.

[pmid18172497-8] Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ. TRPC channel activation by extracellular thioredoxin. Nature. January 2008, 451 (7174): 69–72. PMC 2645077  . PMID 18172497. doi:10.1038/nature06414.

[pmid12858178-9] Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat. Neurosci. August 2003, 6 (8): 837–45. PMID 12858178. S2CID 7523946. doi:10.1038/nn1092.

[pmid12857742-10] Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem. October 2003, 278 (40): 39014–9. PMID 12857742. doi:10.1074/jbc.M306705200  .

[pmid12032305-11] 11.0 ^11.1 Hofmann T, Schaefer M, Schultz G, Gudermann T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc. Natl. Acad. Sci. U.S.A. May 2002, 99 (11): 7461–6. PMC 124253  . PMID 12032305. doi:10.1073/pnas.102596199  .

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