匹立尼酸

化合物

匹立尼酸是一种有机化合物,化学式为C14H14ClN3O2S,它是过氧化物酶体增殖物激活受体α英语peroxisome proliferator-activated receptor alpha(PPARα)激动剂,目前处于实验研究中,用于预防由于心肌细胞内脂质积累而导致的严重心功能障碍、心肌病和心力衰竭。[1]它在1974年被发现。[2]

匹立尼酸
识别信息
  • 2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)acetic acid
CAS号50892-23-4
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.150.489 編輯維基數據鏈接
化学信息
化学式C14H14ClN3O2S
摩尔质量323.80 g·mol−1
3D模型(JSmol英语JSmol
  • Cc1cccc(c1C)Nc2cc(nc(n2)SCC(=O)O)Cl
  • InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
  • Key:SZRPDCCEHVWOJX-UHFFFAOYSA-N

参考文献

编辑
  1. ^ Wölkart G, Schrammel A, Dörffel K, Haemmerle G, Zechner R, Mayer B. Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARα agonist. British Journal of Pharmacology. January 2012, 165 (2): 380–9. PMC 3268192 . PMID 21585347. doi:10.1111/j.1476-5381.2011.01490.x. 
  2. ^ Santilli AA, Scotese AC, Tomarelli RM. A potent antihypercholesterolemic agent: (4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio) acetic acid (Wy-14643). Experientia. October 1974, 30 (10): 1110–1. PMID 4435102. S2CID 12658837. doi:10.1007/BF01923636.