[S-]-UH-301,是一种科学研究中常用的研究化學品及药物。是一种选择性5-HT1A受体沉默拮抗剂[1]結構上與8-OH-DPAT相似。[1] UH-301會令小鼠產生头部抽搐反应,是5-HT2A激动剂药物的典型反应,因此可用來研究5-HT1A受体活性如何调节下游5-HT2A受体。[2]

UH-301
Skeletal formula of UH-301
Space-filling model of the UH-301 molecule
识别信息
  • (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin
CAS号127126-22-1  checkY
IUPHAR/BPS
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C16H24FNO
摩尔质量265.37 g·mol−1
3D模型(JSmol英语JSmol
  • C2Cc1c(c(O)ccc1F)CC2N(CCC)CCC

參見

编辑

参考文獻

编辑
  1. ^ 1.0 1.1 Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.. J Pharmacol Exp Ther. 1991, 258 (1): 58–65. PMID 1830099. 
  2. ^ Darmani, N. A.; Reeves, S. L. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology Biochemistry and Behavior. 1996, 55 (1): 1–10. PMID 8870031. doi:10.1016/0091-3057(96)00072-X.