GS-6620
GS-6620是一种核苷酸类的抗病毒药物,被开发用于治疗丙型肝炎。尽管它在早期测试中显示出有效的抗病毒作用[1][2],但由于它在肠道中的吸收率低且效果不稳定(无法预测血液中的浓度),未能成功制成口服剂。[3][4]目前进行的研究主要针对其它疾病(如埃博拉出血热)[5][6]的治疗。
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商品名 | GS-6620 |
法律规范状态 | |
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识别信息 | |
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CAS号 | 1350735-70-4 |
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CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C29H37N6O9P |
摩尔质量 | 644.6 |
3D模型(JSmol) | |
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参考文献
编辑- ^ Cho A, Zhang L, Xu J, Lee R, Butler T, Metobo S, et al. Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. Journal of Medicinal Chemistry. March 2014, 57 (5): 1812–25. PMID 23547794. doi:10.1021/jm400201a.
- ^ Feng JY, Cheng G, Perry J, Barauskas O, Xu Y, Fenaux M, et al. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrobial Agents and Chemotherapy. 2014, 58 (4): 1930–42. PMC 4023746 . PMID 24419349. doi:10.1128/AAC.02351-13.
- ^ Murakami E, Wang T, Babusis D, Lepist EI, Sauer D, Park Y, et al. Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620. Antimicrobial Agents and Chemotherapy. 2014, 58 (4): 1943–51. PMC 4023801 . PMID 24419340. doi:10.1128/AAC.02350-13.
- ^ Gentile I, Coppola N, Buonomo AR, Zappulo E, Borgia G. Investigational nucleoside and nucleotide polymerase inhibitors and their use in treating hepatitis C virus. Expert Opinion on Investigational Drugs. September 2014, 23 (9): 1211–23. PMID 24848437. doi:10.1517/13543784.2014.921680.
- ^ De Clercq E. C-Nucleosides To Be Revisited. Journal of Medicinal Chemistry. March 2016, 59 (6): 2301–11. PMID 26513594. doi:10.1021/acs.jmedchem.5b01157.
- ^ De Clercq E. New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections. Chemistry, an Asian Journal. November 2019, 14 (22): 3962–3968. PMID 31389664. doi:10.1002/asia.201900841.