用户:Surroundedbyluv/草稿01

Solute carrier family 6 (neurotransmitter transporter), member 4
Solute carrier family 6 (neurotransmitter transporter), member 4
标识
代号	SLC6A4; 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT
扩展标识	遗传学：182138 鼠基因：96285 同源基因：817 ChEMBL: 228 GeneCards: SLC6A4 Gene
基因本体论描述
分子功能	· serotonin:sodium symporter activity; · protein binding; · monoamine transmembrane transporter activity; · serotonin transmembrane transporter activity; · myosin binding; · syntaxin-1 binding; · Rab GTPase binding; · cocaine binding; · protein homodimerization activity; · nitric-oxide synthase binding; · actin filament binding;
细胞成分	· cytosol; · plasma membrane; · integral component of plasma membrane; · endosome membrane; · endomembrane system; · neuron projection; · membrane raft;
生物过程	· response to hypoxia; · serotonin transport; · synaptic transmission; · response to nutrient; · memory; · circadian rhythm; · response to toxic substance; · positive regulation of gene expression; · monoamine transport; · thalamus development; · negative regulation of cerebellar granule cell precursor proliferation; · negative regulation of synaptic transmission, dopaminergic; · response to estradiol; · social behavior; · vasoconstriction; · response to drug; · sperm ejaculation; · negative regulation of neuron differentiation; · positive regulation of cell cycle; · negative regulation of organ growth; · brain morphogenesis; · protein oligomerization; · protein homooligomerization; · serotonin uptake; · transmembrane transport; · cellular response to retinoic acid; · cellular response to cGMP;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	6532
Ensembl	ENSG00000108576
UniProt	P31645
mRNA序列	NM_001045
蛋白序列	NP_001036
基因位置	Chr 17:; 30.19 – 30.24 Mb
PubMed查询	[1]
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血清素转运体 (SERT 或 5-HTT)，钠离子依赖型血清素转运体及溶质载体家族6成员4 是一种在人体中 SLC6A4基因所编码的蛋白质。SERT 是一种负责传送突触间隙的血清素到突触前神经元的单胺转运蛋白。

功能

血清素转运体将血清素从突触间隙发送回突触终扣，阻止了血清素的作用，同时令突触前神经元能够重新运用突触间隙的血清素。

神经元之间的沟通是由神经传导物质，如细胞之间的血清素转运来进行。因血清素转运体使血清素得以重新运用；平冲了血清素于突触间隙的浓度，因此其作用于接收神经元的受体上。

血清素转运体也存在于血小板中，作用为一种使血管收缩的物质。

血清素

外部链接

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