地諾帕明

化合物

地諾帕明INN:denopamine)是一種強心藥,它可充當β1腎上腺素受體激動劑[1]它用於治療心絞痛[2]也可能在治療充血性心力衰竭[3] 和清除肺水腫方面具有潛在用途。[4]它在日本以商品名Kalgut(カルグート)上市,有5毫克和10毫克片劑以及5%細顆粒劑可供選擇。[5]

地諾帕明
臨床資料
AHFS/Drugs.com國際藥品名稱
給藥途徑口服片劑
ATC碼
  • 未分配
法律規範狀態
法律規範
  • Rx-only (JP)
識別資訊
  • 4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
CAS號71771-90-9
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.163.233 編輯維基數據鏈接
化學資訊
化學式C18H23NO4
摩爾質量317.39 g·mol−1
3D模型(JSmol英語JSmol
  • O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C

參考資料

編輯
  1. ^ Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002, 18 (7): 407–13. PMID 12487507. S2CID 25048757. doi:10.1185/030079902125001119. 
  2. ^ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. April 2006, 108 (2): 281–3. PMID 15913812. doi:10.1016/j.ijcard.2005.03.012. 
  3. ^ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. September 1998, 32 (3): 808–15. PMID 9741531. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223 . 
  4. ^ Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, et al. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. February 2001, 85 (2): 161–6. PMID 11286398. doi:10.1254/jjp.85.161 . 
  5. ^ Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information (PDF). Mitsubishi Tanabe Pharma Corporation. [6 March 2016]. (原始內容存檔 (PDF)於2024-03-31) (Japanese).