地诺帕明

化合物

地诺帕明INN:denopamine)是一种强心药,它可充当β1肾上腺素受体激动剂[1]它用于治疗心绞痛[2]也可能在治疗充血性心力衰竭[3] 和清除肺水肿方面具有潜在用途。[4]它在日本以商品名Kalgut(カルグート)上市,有5毫克和10毫克片剂以及5%细颗粒剂可供选择。[5]

地诺帕明
临床资料
AHFS/Drugs.com国际药品名称
给药途径口服片剂
ATC码
  • 未分配
法律规范状态
法律规范
  • Rx-only (JP)
识别信息
  • 4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
CAS号71771-90-9
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.163.233 编辑维基数据链接
化学信息
化学式C18H23NO4
摩尔质量317.39 g·mol−1
3D模型(JSmol英语JSmol
  • O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C

参考资料

编辑
  1. ^ Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002, 18 (7): 407–13. PMID 12487507. S2CID 25048757. doi:10.1185/030079902125001119. 
  2. ^ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. April 2006, 108 (2): 281–3. PMID 15913812. doi:10.1016/j.ijcard.2005.03.012. 
  3. ^ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. September 1998, 32 (3): 808–15. PMID 9741531. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223 . 
  4. ^ Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, et al. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. February 2001, 85 (2): 161–6. PMID 11286398. doi:10.1254/jjp.85.161 . 
  5. ^ Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information (PDF). Mitsubishi Tanabe Pharma Corporation. [6 March 2016]. (原始内容存档 (PDF)于2024-03-31) (Japanese).