藏紅花醛
藏紅花醛（英語：Safranal）是從藏紅花中分離出來的有機化合物，藏紅花是由番紅花（Crocus sativus）柱頭組成的香料。它是藏紅花香氣的主要成分。
| Safranal | |
|---|---|
| |
| IUPAC名 2,6,6-Trimethylcyclohexa-1,3-diene-1-carbaldehyde | |
| 識別 | |
| CAS號 | 116-26-7 
|
| PubChem | 61041 |
| ChemSpider | 55000 |
| SMILES |
|
| ChEBI | 53169 |
| 性質 | |
| 化學式 | C10H14O |
| 摩爾質量 | 150.21 g/mol g·mol⁻¹ |
| 密度 | 0.9734 g/cm3 |
| 沸點 | 70 °C（343 K） |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
藥理學 編輯
藏紅花醛在動物模型中是一種有效的抗驚厥藥，被證明可作為GABAA受體的激動劑。[1][2]藏紅花醛還具有高抗氧化和自由基清除活性，[3][4]以及體外對癌細胞的細胞毒性。[5]其抗癌作用機制之一涉及破壞細胞微管的正常組裝動力學。[6]它在動物身上和人類初步研究中也被證明具有抗抑鬱特性。[7][8]
天然來源 編輯
藏紅花醛可以在一下物種中發現：[9]
參考資料 編輯
- ^ Hosseinzadeh H; Talebzadeh F. Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia. December 2005, 76 (7–8): 722–4. PMID 16253437. doi:10.1016/j.fitote.2005.07.008.
- ^ Hosseinzadeh H; Sadeghnia HR. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine. April 2007, 14 (4): 256–62. PMID 16707256. doi:10.1016/j.phymed.2006.03.007.
- ^ Hosseinzadeh H; Sadeghnia HR. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. Journal of Pharmacy & Pharmaceutical Sciences. 2005, 8 (3): 394–9 [2023-12-28]. PMID 16401389. （原始內容存檔於2016-03-04）.
- ^ Assimopoulou AN; Sinakos Z; Papageorgiou VP. Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytotherapy Research. November 2005, 19 (11): 997–1000. PMID 16317646. S2CID 23907085. doi:10.1002/ptr.1749.
- ^ Escribano J; Alonso GL; Coca-Prados M; Fernandez JA. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Letters. February 1996, 100 (1–2): 23–30. PMID 8620447. doi:10.1016/0304-3835(95)04067-6
.
- ^ Cheriyamundath S, Choudhary S, and Lopus M (2017) Safranal inhibits HeLa cell viability by perturbing the reassembly potential of microtubules. Phytother Res, 32, 170-173. doi: 10.1002/ptr.5938. PMID 29024138
- ^ Hosseinzadeh H; Karimi G; Niapoor M. Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice. Acta Horticulturae. 2004, 650 (650): 435–45. doi:10.17660/ActaHortic.2004.650.54.
- ^ Akhondzadeh S; Fallah-Pour H; Afkham K; Jamshidi AH; Khalighi-Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial ISRCTN45683816. BMC Complementary and Alternative Medicine. September 2004, 4: 12. PMC 517724 . PMID 15341662. doi:10.1186/1472-6882-4-12 .
- ^ List of Chemicals. sun.ars-grin.gov. [2008-03-02].
- ^ Yan JH; Tang KW; Zhong M; Deng NH. [Determination of chemical components of volatile oil from Cuminum cyminum L. by gas chromatography-mass spectrometry]. Se Pu. November 2002, 20 (6): 569–72. PMID 12683011 （中文）.
- ^ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 Ramin Rezaee; Hossein Hosseinzadeh. [Safranal: From an Aromatic Natural Product to a Rewarding Pharmacological Agent]. Iranian Journal of Basic Medical Sciences. January 2013, 16 (1): 12–26. PMC 3637901 . PMID 23638289.
