胱天蛋白酶14
位於19號人類染色體的基因
胱天蛋白酶14（英語：Caspase 14）是一種在人類中由CASP14基因編碼的酶。[6][7][8]
| 胱天蛋白酶14 | |||||||||||||||||||||||||
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| 識別號 | |||||||||||||||||||||||||
| 別名 | CASP14；, caspase 14, ARCI12 | ||||||||||||||||||||||||
| 外部ID | OMIM：605848 MGI：1335092 HomoloGene：36304 GeneCards：CASP14 | ||||||||||||||||||||||||
| 為以下藥物的標靶 | |||||||||||||||||||||||||
| emricasan[1] | |||||||||||||||||||||||||
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| 直系同源 | |||||||||||||||||||||||||
| 物種 | 人類 | 小鼠 | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| mRNA序列 | |||||||||||||||||||||||||
| 蛋白序列 | |||||||||||||||||||||||||
| 基因位置（UCSC） | Chr 19: 15.05 – 15.06 Mb | Chr 10: 78.55 – 78.55 Mb | |||||||||||||||||||||||
| PubMed查找 | [4] | [5] | |||||||||||||||||||||||
| 維基數據 | |||||||||||||||||||||||||
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胱天蛋白酶14屬於胱天蛋白酶家族的成員。胱天蛋白酶的連續活化在細胞凋亡的執行階段發揮着核心作用。胱天蛋白酶以無活性的酶原形式存在，在保守的天冬氨酸殘基處經歷蛋白水解加工，產生一大一小兩個亞基，然後二聚化形成活性酶。該酶已被證明在體外被胱天蛋白酶8和10加工和活化，而在體內則被抗Fas促效劑抗體或TNF相關凋亡誘導配體加工和活化。這種胱天蛋白酶的表達和加工可能參與角質形成細胞終末分化，這對於皮膚屏障的形成很重要。[8]
根據人類蛋白質圖譜[9]，CASP14蛋白在人類皮膚中富集，主要表達於表皮上層。根據細胞圖譜，該蛋白質主要定位於細胞質。[10]
參見 編輯
參考文獻 編輯
- ^ 對Caspase 14起作用的藥物；在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000105141 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000005355 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P. Identification of a new caspase homologue: caspase-14. Cell Death Differ. May 1999, 5 (10): 838–46. PMID 10203698. doi:10.1038/sj.cdd.4400444
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- ^ Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM. Caspase-14 is a novel developmentally regulated protease. J Biol Chem. Dec 1998, 273 (45): 29648–53. PMID 9792675. doi:10.1074/jbc.273.45.29648 .
- ^ 8.0 8.1 Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase.
- ^ Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina. Tissue-based map of the human proteome. Science. 2015-01-23, 347 (6220): 1260419. ISSN 0036-8075. PMID 25613900. S2CID 802377. doi:10.1126/science.1260419 （英語）.
- ^ Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Blal, Hammou Ait; Alm, Tove; Asplund, Anna; Björk, Lars. A subcellular map of the human proteome. Science. 2017-05-26, 356 (6340): eaal3321. ISSN 0036-8075. PMID 28495876. S2CID 10744558. doi:10.1126/science.aal3321 （英語）.
拓展閱讀 編輯
- Rasmussen HH, van Damme J, Puype M, et al. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.. Electrophoresis. 1993, 13 (12): 960–9. PMID 1286667. S2CID 41855774. doi:10.1002/elps.11501301199.
- Ahmad M, Srinivasula SM, Hegde R, et al. Identification and characterization of murine caspase-14, a new member of the caspase family.. Cancer Res. 1998, 58 (22): 5201–5. PMID 9823333.
- Eckhart L, Ban J, Fischer H, Tschachler E. Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation.. Biochem. Biophys. Res. Commun. 2000, 277 (3): 655–9. PMID 11062009. doi:10.1006/bbrc.2000.3698.
- Eckhart L, Declercq W, Ban J, et al. Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.. J. Invest. Dermatol. 2001, 115 (6): 1148–51. PMID 11121154. doi:10.1046/j.1523-1747.2000.00205.x .
- Lippens S, Kockx M, Knaapen M, et al. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.. Cell Death Differ. 2001, 7 (12): 1218–24. PMID 11175259. doi:10.1038/sj.cdd.4400785 .
- Pistritto G, Jost M, Srinivasula SM, et al. Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.. Cell Death Differ. 2003, 9 (9): 995–1006. PMID 12181750. S2CID 23933663. doi:10.1038/sj.cdd.4401061.
- Chien AJ, Presland RB, Kuechle MK. Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.. Biochem. Biophys. Res. Commun. 2002, 296 (4): 911–7. PMID 12200134. doi:10.1016/S0006-291X(02)02015-6.
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- Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
- Lippens S, Kockx M, Denecker G, et al. Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.. Am. J. Pathol. 2004, 165 (3): 833–41. PMC 1618612 . PMID 15331408. doi:10.1016/s0002-9440(10)63346-9.
- Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
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