腺苷再摄取抑制剂
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腺苷再摄取抑制剂（Adenosine reuptake inhibitor，缩写为AdoRI）是一类药物，它通过阻断一个或多个平衡核苷转运蛋白（ENTs）的作用，作为嘌呤核苷和神经递质腺苷的再摄取抑制剂。[1][2][3]这继而导致腺苷的细胞外浓度增加，因此腺苷能神经传递增加。
参考资料
编辑- ^ SenGupta DJ, Unadkat JD. Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep. Biochem Pharmacol. 2004, 67 (3): 453–458. PMID 15037197. doi:10.1016/j.bcp.2003.09.018.
- ^ Endres CJ, Sengupta DJ, Unadkat JD. Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1. Biochem J. 2004, 380 (1): 131–137. PMC 1224139
. PMID 14759222. doi:10.1042/BJ20031880.
- ^ Chaudary N, Naydenova Z, Shuralyova I, Coe IR. The adenosine transporter, mENT1, is a target for adenosine receptor signaling and protein kinase Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line, HL-1. J Pharmacol Exp Ther. 2004, 310 (3): 1190–1198. PMID 15131243. doi:10.1124/jpet.104.067157.
