HP-505
HP-505是一种有机化合物，化学式为C18H19NO。它是由赫美罗制药公司研发的三重再摄取抑制剂。[1]HP-505在小鼠试验中发现是丁苯那嗪诱导的上睑下垂的有效抑制剂，这表明它可能具有抗抑郁活性。[2]
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| 识别信息 | |
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| CAS号 | 59142-94-8  |
| PubChem CID | |
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| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C18H19NO |
| 摩尔质量 | 265.36 g·mol−1 |
| 3D模型（JSmol） | |
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药理学
编辑| 5-HT | NE | DA | NE:5-HT | DA:5-HT |
|---|---|---|---|---|
| 0.19 ± 0.04 | 0.34 ± 0.1 | 0.66 ± 0.15 | 1.8 | 3.5 |
化学性质
编辑HP-505在碳酸氢钠存在下，可以和2-氯-4-硝基吡啶-1-氧化物反应，得到N-(1-氧化-4-硝基吡啶-2-基)-HP-505。[3]
参考文献
编辑- ^ 1.0 1.1 Meyerson, Laurence R; Ong, Helen H; Martin, Lawrence L; Ellis, Daniel B. Effect of antidepressant agents on β-adrenergic receptor and neurotransmitter regulatory systems. Pharmacology Biochemistry and Behavior. June 1980, 12 (6): 943–948. PMID 6105676. S2CID 45400599. doi:10.1016/0091-3057(80)90457-8.
- ^ Klioze, SS; Bauer, VJ; Geyer HM, 3rd. Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 2. Compounds containing a heteroatom attached to nitrogen.. Journal of Medicinal Chemistry. April 1977, 20 (4): 610–2. PMID 850252. doi:10.1021/jm00214a039.
- ^ Allerton, Charlotte Moira Norfor; Owen, Dafydd Rhys; Ryckmans, Thomas; Stammen, Blanda Luzia Christa. Spiropiperidine derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as delta opioid receptor agonists. 2007 WO 2007057775 A1.