癸基三苯基𬭸

化合物

癸基三苯基𬭸(DTPP)是一种有机磷阳离子,分子式为C10H21P(C6H5)3+。它是亲脂性季𬭸阳离子。它是许多线粒体靶向药物的基础,包括MitoQ、MitoE和SkQ。它首先插入内膜,再与线粒体基质结合。[1][2]DTPP本身可以导致肾组织中的线粒体肿胀,可能与膜通透性的增加有关。[3]

癸基三苯基𬭸
IUPAC名
Dodecyltri(phenyl)phosphanium
别名 Dodecyltriphenylphosphonium, C12TPP(+), DTPP
识别
CAS号 17895-72-6  checkY
PubChem 84956
ChemSpider 76637
SMILES
 
  • CCCCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
ChEBI 82636
性质
化学式 C30H40P+
摩尔质量 431.61 g·mol⁻¹
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

常见盐类

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常见的癸基三苯基𬭸盐如下:

名称 化学式 CAS号
癸基三苯基溴化𬭸 C10H21P(C6H5)3Br 15510-55-1
癸基三苯基氯化𬭸 C10H21P(C6H5)3Cl 84902-22-7
癸基三苯基碘化𬭸 C10H21P(C6H5)3I 123966-50-7
癸基三苯基𬭸对甲苯磺酸盐[4] C10H21P(C6H5)3(C7H7SO3) 95736-41-7
四氯合铂(II)酸癸基三苯基𬭸[5] [C10H21P(C6H5)3]2[PtCl4] 77773-17-2

参考文献

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  1. ^ Murphy, MP. Targeting lipophilic cations to mitochondria.. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2008, 1777 (7–8): 1028–31. PMID 18439417. doi:10.1016/j.bbabio.2008.03.029 . 
  2. ^ Leo, S; Szabadkai, G; Rizzuto, R. The mitochondrial antioxidants MitoE(2) and MitoQ(10) increase mitochondrial Ca(2+) load upon cell stimulation by inhibiting Ca(2+) efflux from the organelle.. Annals of the New York Academy of Sciences. December 2008, 1147: 264–74. PMC 2676430 . PMID 19076448. doi:10.1196/annals.1427.019. 
  3. ^ Gottwald, EM; Duss, M; Bugarski, M; Haenni, D; Schuh, CD; Landau, EM; Hall, AM. The targeted anti-oxidant MitoQ causes mitochondrial swelling in kidney tissue. It and depolarization in kidney tissue.. Physiological Reports. April 2018, 6 (7): e13667. PMC 5880956 . PMID 29611340. doi:10.14814/phy2.13667. 
  4. ^ Anderson, J. H.; Bugner, D. E.; DeMejo, L. P.; Guistina, R. A.; Zumbulyadis, N. Charge agent studies: I. Charge agent surface concentration and charging behavior. Journal of Imaging Science and Technology, 1993. 37 (5): 431-439.
  5. ^ Brovko, V. S.; Skvortsov, N. K.; Reikhsfel'd, V. O. Phosphonium salt platinites and platinates as hydrosilylation catalysts. Zhurnal Obshchei Khimii, 1981. 51 (2): 487.

延伸阅读

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