癸基三苯基鏻

化合物

癸基三苯基鏻(DTPP)是一種有機磷陽離子,分子式為C10H21P(C6H5)3+。它是親脂性季陽離子。它是許多粒線體靶向藥物的基礎,包括MitoQ、MitoE和SkQ。它首先插入內膜,再與粒線體基質結合。[1][2]DTPP本身可以導致腎組織中的粒線體腫脹,可能與膜通透性的增加有關。[3]

癸基三苯基鏻
IUPAC名
Dodecyltri(phenyl)phosphanium
別名 Dodecyltriphenylphosphonium, C12TPP(+), DTPP
識別
CAS號 17895-72-6  checkY
PubChem 84956
ChemSpider 76637
SMILES
 
  • CCCCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
ChEBI 82636
性質
化學式 C30H40P+
莫耳質量 431.61 g·mol⁻¹
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

常見鹽類

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常見的癸基三苯基鏻鹽如下:

名稱 化學式 CAS號
癸基三苯基溴化鏻 C10H21P(C6H5)3Br 15510-55-1
癸基三苯基氯化鏻 C10H21P(C6H5)3Cl 84902-22-7
癸基三苯基碘化鏻 C10H21P(C6H5)3I 123966-50-7
癸基三苯基鏻對甲苯磺酸鹽[4] C10H21P(C6H5)3(C7H7SO3) 95736-41-7
四氯合鉑(II)酸癸基三苯基鏻[5] [C10H21P(C6H5)3]2[PtCl4] 77773-17-2

參考文獻

編輯
  1. ^ Murphy, MP. Targeting lipophilic cations to mitochondria.. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2008, 1777 (7–8): 1028–31. PMID 18439417. doi:10.1016/j.bbabio.2008.03.029 . 
  2. ^ Leo, S; Szabadkai, G; Rizzuto, R. The mitochondrial antioxidants MitoE(2) and MitoQ(10) increase mitochondrial Ca(2+) load upon cell stimulation by inhibiting Ca(2+) efflux from the organelle.. Annals of the New York Academy of Sciences. December 2008, 1147: 264–74. PMC 2676430 . PMID 19076448. doi:10.1196/annals.1427.019. 
  3. ^ Gottwald, EM; Duss, M; Bugarski, M; Haenni, D; Schuh, CD; Landau, EM; Hall, AM. The targeted anti-oxidant MitoQ causes mitochondrial swelling in kidney tissue. It and depolarization in kidney tissue.. Physiological Reports. April 2018, 6 (7): e13667. PMC 5880956 . PMID 29611340. doi:10.14814/phy2.13667. 
  4. ^ Anderson, J. H.; Bugner, D. E.; DeMejo, L. P.; Guistina, R. A.; Zumbulyadis, N. Charge agent studies: I. Charge agent surface concentration and charging behavior. Journal of Imaging Science and Technology, 1993. 37 (5): 431-439.
  5. ^ Brovko, V. S.; Skvortsov, N. K.; Reikhsfel'd, V. O. Phosphonium salt platinites and platinates as hydrosilylation catalysts. Zhurnal Obshchei Khimii, 1981. 51 (2): 487.

延伸閱讀

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