CD61

CD61
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4O02、1JV2、1KUP、1KUZ、1L5G、1M1X、1M8O、1MIZ、1MK7、1MK9、1S4X、1TYE、1U8C、2K9J、2KNC、2KV9、2L1C、2L91、2LJD、2LJE、2LJF、2MTP、2Q6W、2RMZ、2RN0、2VC2、2VDK、2VDL、2VDM、2VDN、2VDP、2VDQ、2VDR、3FCS、3FCU、3IJE、3NID、3NIF、3NIG、3T3M、3T3P、3ZDX、3ZDY、3ZDZ、3ZE0、3ZE1、3ZE2、4CAK、4G1E、4G1M、4MMX、4MMY、4MMZ、5HDB、4Z7Q、4Z7O、4Z7N
识别号
别名	ITGB3；, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2
外部ID	OMIM：173470 MGI：96612 HomoloGene：55444 GeneCards：ITGB3
相关疾病
	血小板无力症、platelet-type bleeding disorder 16
为以下药物的标靶
	cilengitide、依非巴特、tirofiban hydrochloride hydrate
基因位置（人类）
染色体	17号染色体
终止	47,313,743 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	104,561,302 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• vascular endothelial growth factor receptor 2 binding; • fibronectin binding; • virus receptor activity; • extracellular matrix binding; • protein disulfide isomerase activity; • 蛋白酶结合; • platelet-derived growth factor receptor binding; • 血浆蛋白结合; • 相同蛋白质结合; • 酶结合; • cell adhesion molecule binding; • neuregulin binding; • coreceptor activity; • fibroblast growth factor binding; • insulin-like growth factor I binding; • C-X3-C chemokine binding; • integrin binding; • fibrinogen binding;
细胞组分	• integral component of membrane; • cell projection; • alphav-beta3 integrin-vitronectin complex; • 膜; • 粘着斑; • 黑色素体; • receptor complex; • 细胞膜; • integral component of plasma membrane; • ruffle membrane; • cell surface; • 细胞连接; • integrin complex; • platelet alpha granule membrane; • integrin alphav-beta3 complex; • 外排体; • lamellipodium membrane; • 细胞核; • microvillus membrane; • filopodium membrane; • alphav-beta3 integrin-IGF-1-IGF1R complex; • alphav-beta3 integrin-PKCalpha complex; • alphav-beta3 integrin-HMGB1 complex; • glutamatergic synapse; • 突触;
生物学过程	• negative regulation of lipoprotein metabolic process; • apolipoprotein A-I-mediated signaling pathway; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • positive regulation of protein phosphorylation; • regulation of cell migration; • negative chemotaxis; • positive regulation of endothelial cell proliferation; • tube development; • heterotypic cell-cell adhesion; • angiogenesis involved in wound healing; • 伤口愈合; • platelet degranulation; • 凝血; • extracellular matrix organization; • smooth muscle cell migration; • positive regulation of endothelial cell migration; • 增殖; • cell-substrate adhesion; • vascular endothelial growth factor receptor signaling pathway; • 细胞粘附; • positive regulation of peptidyl-tyrosine phosphorylation; • mesodermal cell differentiation; • cell-substrate junction assembly; • integrin-mediated signaling pathway; • negative regulation of lipid storage; • substrate adhesion-dependent cell spreading; • negative regulation of lipid transport; • cell-matrix adhesion; • viral process; • regulation of bone resorption; • platelet aggregation; • 细胞迁移; • negative regulation of macrophage derived foam cell differentiation; • activation of protein kinase activity; • leukocyte migration; • cell adhesion mediated by integrin; • platelet activation; • apoptotic cell clearance; • regulation of postsynaptic neurotransmitter receptor internalization; • regulation of protein localization; • regulation of serotonin uptake;
	Sources:Amigo / QuickGO
直系同源
	3690
	16416
	ENSG00000259207
	ENSMUSG00000020689
	P05106
	O54890
	NM_000212
	NM_016780
	NP_000203
	NP_058060
	维基数据
查看/编辑人类	查看/编辑小鼠

整联蛋白β-3（Integrin β3）或 CD61（Cluster of differentiation 61）是一种蛋白质，在人类基因组中由 ITGB3 基因编码。^[7] CD61 是一种在血小板上表达的分化簇。^[8]

参考文献

^ 與CD61相關的疾病；在維基數據上查看/編輯參考.
^ 對CD61起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000259207 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000020689 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa. J Clin Invest. August 1988, 81 (6): 1993–8. PMC 442653  . PMID 2454952. doi:10.1172/JCI113548.
^ Heemskerk, J. W. M.; Mattheij, N. J. A.; Cosemans, J. M. E. M. Platelet-based coagulation: different populations, different functions. Journal of Thrombosis and Haemostasis. 2013, 11 (1): 2–16. ISSN 1538-7933. doi:10.1111/jth.12045.

进一步阅读

Bray PF. Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.. Thromb. Haemost. 1995, 72 (4): 492–502. PMID 7878622.
Bennett JS. Platelet-fibrinogen interactions.. Ann. N. Y. Acad. Sci. 2001, 936: 340–54. Bibcode:2001NYASA.936..340B. PMID 11460491. doi:10.1111/j.1749-6632.2001.tb03521.x.
Sajid M, Stouffer GA. The role of alpha(v)beta3 integrins in vascular healing.. Thromb. Haemost. 2002, 87 (2): 187–93. PMID 11858476.
Quinn MJ, Byzova TV, Qin J, et al. Integrin alphaIIbbeta3 and its antagonism.. Arterioscler. Thromb. Vasc. Biol. 2004, 23 (6): 945–52. PMID 12637342. doi:10.1161/01.ATV.0000066686.46338.F1.
Charakida M, Tousoulis D, Stefanadis C, Toutouzas P. The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.. Italian Heart Journal. 2003, 4 (1): 17–22. PMID 12690916.
Smith FB, Connor JM, Lee AJ, et al. Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.. Thromb. Res. 2004, 112 (4): 209–16. PMID 14987913. doi:10.1016/j.thromres.2003.11.010.
Fullard JF. The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.. Curr. Pharm. Des. 2004, 10 (14): 1567–76. PMID 15134555. doi:10.2174/1381612043384682.
Cacciari B, Spalluto G. Non peptidic alphavbeta3 antagonists: recent developments.. Curr. Med. Chem. 2005, 12 (1): 51–70. PMID 15638730. doi:10.2174/0929867053363522.
Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 signaling in platelets.. J. Thromb. Haemost. 2005, 3 (8): 1752–62. PMID 16102042. doi:10.1111/j.1538-7836.2005.01429.x.
Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3.. J. Clin. Invest. 2006, 115 (12): 3363–9. PMC 1297263  . PMID 16322781. doi:10.1172/JCI26989.

外部链接

医学主题词表（MeSH）：CD61+Antigens
ITGB3 信息的链接在单元的移徙网关
Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[1] 與CD61相關的疾病；在維基數據上查看/編輯參考.

[2] 對CD61起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000259207 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000020689 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2454952-7] Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa. J Clin Invest. August 1988, 81 (6): 1993–8. PMC 442653  . PMID 2454952. doi:10.1172/JCI113548.

[HeemskerkMattheij2013-8] Heemskerk, J. W. M.; Mattheij, N. J. A.; Cosemans, J. M. E. M. Platelet-based coagulation: different populations, different functions. Journal of Thrombosis and Haemostasis. 2013, 11 (1): 2–16. ISSN 1538-7933. doi:10.1111/jth.12045.

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