NEUROD1
位於2號人類染色體的基因
NEUROD1,(小鼠的同源蛋白質記爲NeuroD1)在人體內是NeuroD蛋白家族下的一個轉錄因子,由NEUROD1基因編碼。NEUROD1在神經系統發育中扮演重要角色,於發育中參與調控多種神經系細胞的分化過程[5][6]。
證據表明NEUROD1與II型糖尿病的發生關係密切[7]。一項研究表明在小鼠大腦內過表達NEUROD1可使神經膠質細胞轉分化爲神經元[8]。
蛋白质相互作用
编辑參考
编辑- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000162992 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000034701 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Poulin, G; Turgeon, B; Drouin, J. NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Molecular and Cellular Biology. 1997-11, 17 (11): 6673–6682 [2021-11-10]. ISSN 0270-7306. PMC 232521 . PMID 9343431. doi:10.1128/MCB.17.11.6673. (原始内容存档于2021-11-10) (英语).
- ^ NEUROD1. UniProt. [2018-02-25]. (原始内容存档于2018-02-25).
- ^ NEUROD1 neuronal differentiation 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. (原始内容存档于2021-11-10).
- ^ Guo, Ziyuan; Zhang, Lei; Wu, Zheng; Chen, Yuchen; Wang, Fan; Chen, Gong. In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model. Cell Stem Cell. 2014-02, 14 (2): 188–202 [2021-11-10]. PMC 3967760 . PMID 24360883. doi:10.1016/j.stem.2013.12.001. (原始内容存档于2022-02-17) (英语).
- ^ Ratineau, Christelle; Petry, Mary W.; Mutoh, Hiroyuki; Leiter, Andrew B. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. The Journal of Biological Chemistry. 2002-03-15, 277 (11): 8847–8853 [2021-11-10]. ISSN 0021-9258. PMID 11788592. doi:10.1074/jbc.M110747200. (原始内容存档于2021-11-10).
- ^ Zhao, Li; Guo, Min; Matsuoka, Taka-Aki; Hagman, Derek K.; Parazzoli, Susan D.; Poitout, Vincent; Stein, Roland. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. The Journal of Biological Chemistry. 2005-03-25, 280 (12): 11887–11894 [2021-11-10]. ISSN 0021-9258. PMID 15665000. doi:10.1074/jbc.M409475200. (原始内容存档于2022-04-19).
- ^ Marcora, E.; Gowan, K.; Lee, J. E. Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2. Proceedings of the National Academy of Sciences. 2003-08-05, 100 (16): 9578–9583. ISSN 0027-8424. PMC 170960 . PMID 12881483. doi:10.1073/pnas.1133382100 (英语).
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