抑癌蛋白M

OSM
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1EVS
识别号
别名	OSM；, Osm, OncoM, oncostatin M
外部ID	OMIM：165095 MGI：104749 HomoloGene：10741 GeneCards：OSM
基因位置（人类）
染色体	22号染色体
终止	30,266,851 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	4,191,026 bp
基因本体
分子功能	• 细胞因子活性; • oncostatin-M receptor binding; • 生长因子活性;
细胞组分	• 细胞外区域; • 细胞外空间;
生物学过程	• oncostatin-M-mediated signaling pathway; • positive regulation of peptidyl-serine phosphorylation; • multicellular organism development; • 免疫反应; • positive regulation of cell population proliferation; • positive regulation of acute inflammatory response; • regulation of growth; • 细胞增殖; • negative regulation of hormone secretion; • positive regulation of cell division; • positive regulation of MAPK cascade; • negative regulation of cell population proliferation; • positive regulation of transcription by RNA polymerase II; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • positive regulation of peptidyl-tyrosine phosphorylation; • cytokine-mediated signaling pathway; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of inflammatory response; • positive regulation of protein kinase B signaling; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
直系同源
	5008
	18413
	ENSG00000099985
	ENSMUSG00000058755
	P13725
	P53347
	NM_020530; NM_001319108
	NM_001013365
	NP_001306037; NP_065391
	NP_001013383
	维基数据
查看/编辑人类	查看/编辑小鼠

抑癌蛋白M（英语：Oncostatin M，缩写OSM，也译作制癌蛋白M、抑瘤素M）是由人类基因 OSM 编码的蛋白质^[5]，由209个氨基酸残基组成。OSM是一种多效的细胞因子，属于IL-6家族^[6]，和白血病抑制因子（LIF）在结构和功能上类似^[6]，在肝脏发育、造血作用、炎症反应以及中枢神经系统发育和骨形成中有重要作用^[7]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000099985 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000058755 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rose TM, Bruce AG. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Natl. Acad. Sci. U.S.A. October 1991, 88 (19): 8641–5. PMC 52565  . PMID 1717982. doi:10.1073/pnas.88.19.8641.
^ ^6.0 ^6.1 Tanaka M, Miyajima A. Oncostatin M, a multifunctional cytokine. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 2003, 149: 39–52. ISBN 978-3-540-20213-4. PMID 12811586. doi:10.1007/s10254-003-0013-1.
^ Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest. 2010, 120 (2): 582–92 [2019-12-09]. PMC 2810087  . PMID 20051625. doi:10.1172/JCI40568. （原始内容存档于2020-05-29）. 简明摘要 – ScienceDaily.

延伸阅读

Schieven GL, Kallestad JC, Brown TJ, Ledbetter JA, Linsley PS. Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase. J. Immunol. September 1992, 149 (5): 1676–82. PMID 1324279.
Hermanns HM, Radtke S, Schaper F, Heinrich PC, Behrmann I. Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to the oncostatin M receptor. J. Biol. Chem. December 2000, 275 (52): 40742–8. PMID 11016927. doi:10.1074/jbc.M005408200.

外部链接

医学主题词表（MeSH）：Oncostatin+M

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000099985 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000058755 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1717982-5] Rose TM, Bruce AG. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Natl. Acad. Sci. U.S.A. October 1991, 88 (19): 8641–5. PMC 52565  . PMID 1717982. doi:10.1073/pnas.88.19.8641.

[pmid12811586-6] 6.0 ^6.1 Tanaka M, Miyajima A. Oncostatin M, a multifunctional cytokine. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 2003, 149: 39–52. ISBN 978-3-540-20213-4. PMID 12811586. doi:10.1007/s10254-003-0013-1.

[Walker_2010-7] Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest. 2010, 120 (2): 582–92 [2019-12-09]. PMC 2810087  . PMID 20051625. doi:10.1172/JCI40568. （原始内容存档于2020-05-29）. 简明摘要 – ScienceDaily.

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