抑癌蛋白M(英语:Oncostatin M,缩写OSM,也译作制癌蛋白M抑瘤素M)是由人类基因 OSM 编码的蛋白质[5],由209个氨基酸残基组成。OSM是一种多效的细胞因子,属于IL-6家族[6],和白血病抑制因子(LIF)在结构和功能上类似[6],在肝脏发育、造血作用炎症反应以及中枢神经系统发育和骨形成中有重要作用[7]

OSM
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名OSM;, Osm, OncoM, oncostatin M
外部IDOMIM165095 MGI104749 HomoloGene10741 GeneCardsOSM
基因位置(人类
22号染色体
染色体22号染色体[1]
22号染色体
OSM的基因位置
OSM的基因位置
基因座22q12.2起始30,262,829 bp[1]
终止30,266,851 bp[1]
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_020530
​NM_001319108

NM_001013365

蛋白序列

NP_001306037
​NP_065391

NP_001013383

基因位置​(UCSC)Chr 22: 30.26 – 30.27 MbChr 11: 4.19 – 4.19 Mb
PubMed​查找[3][4]
维基数据
查看/编辑人类查看/编辑小鼠

参考文献

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  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000099985 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000058755 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Rose TM, Bruce AG. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Natl. Acad. Sci. U.S.A. October 1991, 88 (19): 8641–5. PMC 52565 . PMID 1717982. doi:10.1073/pnas.88.19.8641. 
  6. ^ 6.0 6.1 Tanaka M, Miyajima A. Oncostatin M, a multifunctional cytokine. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 2003, 149: 39–52. ISBN 978-3-540-20213-4. PMID 12811586. doi:10.1007/s10254-003-0013-1. 
  7. ^ Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest. 2010, 120 (2): 582–92 [2019-12-09]. PMC 2810087 . PMID 20051625. doi:10.1172/JCI40568. (原始内容存档于2020-05-29). 简明摘要ScienceDaily. 

延伸阅读

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  • Schieven GL, Kallestad JC, Brown TJ, Ledbetter JA, Linsley PS. Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase. J. Immunol. September 1992, 149 (5): 1676–82. PMID 1324279. 
  • Hermanns HM, Radtke S, Schaper F, Heinrich PC, Behrmann I. Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to the oncostatin M receptor. J. Biol. Chem. December 2000, 275 (52): 40742–8. PMID 11016927. doi:10.1074/jbc.M005408200. 

外部链接

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